Semaglutide, formulated as a glucagon-like peptide-1 (GLP-1) receptor agonist, exists as monotherapy in both oral and subcutaneous dosage forms (initially approved oral GLP-1 receptor agonist). The medicine has been launched as a second line therapeutic option for better glycaemic control in patients with type 2 diabetes.
As per Semaglutide manufacturer, it has been promising and safe in adults and elderly individuals with hepatic or renal disorders requiring no dose modification. Cardiovascular (CV) results in trials established that the medicine can scale down various Cardiovascular (CV) risk factors in those with established CV (Cardiovascular) disorders. Semaglutide treatment is well tolerated with no threat of hypoglycaemia in monotherapy but suffers from gastrointestinal side effects.
Both the oral as well as subcutaneous dosage forms of semaglutide have been demonstrated to achieve significant CV enhancements in clinical trials. Semaglutide by Novo Nordisk has been launched clinically and globally marketed as Ozempic (subcutaneous injection, weekly-once dosing; commercially available in 0.5 mg, 1.0 mg dose) and Rybelsus (oral tablets, once-daily dosing; commercially available in 3 mg, 7 mg, and 14 mg dose). Both Rybelsus and Ozempic have been approved by the FDA, European Medicines Agency, Health Canada, and Japanese Health ministry and are under scrutiny by many other existing regulatory authorities.
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